CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium.

Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo.

Pseudomonas aeruginosa (PA) airway infection and bronchial blood vessel proliferation are features of bronchiectasis. Because vascular endothelial growth factor (VEGF)-A regulates angiogenesis, we hypothesised that PA infection induces VEGF synthesis in epithelium and peribronchial angiogenesis. Because epidermal growth factor receptor (EGFR) activation regulates VEGF synthesis in cancer, we al...

The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis.

In this issue of the European Respiratory Journal, MARTIN et al. [1] focus on the life-threatening complication of haemoptysis in cystic fibrosis (CF). The authors examine the role of vascular endothelial growth factor (VEGF)-A on angiogenesis in the normal state and in CF. They report that CF airways at transplantation show increased vascularity and increased VEGF-A expression. In normal human...

Role of vascular endothelial growth factor A in children with acquired airway stenosis.

OBJECTIVES Vascular endothelial growth factor A (VEGF-A) is important in the angiogenic response for wound healing. This study investigated whether VEGF-A may play a role in the pathogenesis of acquired airway stenosis. METHODS Eight lesions from 5 pediatric patients with subglottic stenosis after airway reconstruction (N = 4) or prolonged intubation (N = 1) and normal laryngeal tissue from 5...

Serum and Peritoneal Fluid Levels of Vascular Endothelial Growth Factor in Women with Endometriosis

Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells.

Human airway basal cells are the stem (or progenitor) population of the airway epithelium, and play a central role in anchoring the epithelium to the basement membrane. The anatomic position of basal cells allows for potential paracrine signaling between them and the underlying non-epithelial stromal cells. In support of this, we have previously demonstrated that endothelial cells support growt...